Missed Base with Scoring Runner
With two outs, there is a runner at third base (R3) and a runner at first base (R1). The batter singles to the outfield. R3 scores. R1 arrives safely at third base, but did not touch second base. The batter is safe at first base. When playing action stops, the defense properly appeals that R1 missed second base. The umpires agree and call R1 out for the third out of the inning.
Does R3's run count?